Henrietta Street is the earliest Georgian Street in Dublin, and at the forefront Dublin's later Georgian streetscapes. Construction on the street started in the mid-1720s, on land bought by the Gardiner family in 1721. Construction was still taking place in the 1750s. Gardiner had a mansion, designed by Richard Cassels, built for his own use around 1730.

The street was popularly referred to as Primate's Hill, as one of the houses was owned by the Archbishop of Armagh, although this house, along with two others, was demolished to make way for the Law Library of King's Inns.